Chrono
Finding signals that reset biological clocks
The project aims to find proteins released by cells that help reset biological clocks.
View the project and supervisors →Home / Doctoral Candidates
Doctoral Candidates
12 projects
One shared ambition
Choose a scientific question, discover the team behind it and prepare for your doctoral journey within the network.
Measuring how well individual cell clocks stay in sync
Develop a method to estimate the timing and strength of individual cell clocks from gene activity data.
View the project and supervisors →Finding liver signals that coordinate metabolism across the body
Find signals released by the liver that affect feeding and metabolism in other organs.
View the project and supervisors →How exercise timing affects muscle energy production
Study how exercise at different times of day affects mitochondria, the structures that produce energy in cells.
View the project and supervisors →How PI3K-3 controls daily gene activity in the liver
Study how PI3K-3, a cell signalling protein, controls daily changes in liver gene activity and metabolism.
View the project and supervisors →How diet and hormones affect daily liver metabolism
Understand how reduced-calorie diets change the effects of glucocorticoid hormones on the liver.
View the project and supervisors →How feeding schedules affect liver and gut clocks
Study how clocks in liver and gut cells stay in sync, and how changed feeding schedules disrupt them.
View the project and supervisors →Biological clocks and fat metabolism in human muscle with type 2 diabetes
Study how disrupted muscle clocks in type 2 diabetes affect fats and cell membranes, especially near the insulin receptor.
View the project and supervisors →How metabolic stress affects clocks in fat tissue
Understand how increased metabolic demands disrupt daily rhythms in fat tissue.
View the project and supervisors →Timed treatments to improve metabolism in obesity
Test whether targeting DHODH, an enzyme in mitochondria, at specific times can reproduce some benefits of eating within a daily time window.
View the project and supervisors →Using biological clocks to improve liver graft preservation
Map daily rhythms in human livers and test whether clock treatments can improve graft function and reduce damage from interrupted blood supply.
View the project and supervisors →Developing human pancreatic cells to study daily insulin rhythms
Develop pancreatic β-cells from human induced pluripotent stem cells (hiPSCs) to study biological clocks and insulin release.
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